J. Antimicrob. Chemother. June 2010 V.65  N.6 p.1086-1093 

Reviews

Ronald B. Moss1,*, Richard T. Davey2, Roy T. Steigbigel3 and Fang Fang1

1 NexBio, Inc., San Diego, CA, USA 2 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA 3 Department of Medicine, SUNY at Stony Brook School of Medicine, Stony Brook, NY, USA

The emergence of the 2009 H1N1 pandemic influenza A virus, as well as constant antigenic drift of seasonal influenza, underscores the remarkable versatility of this virus in adapting to the human population. While vaccines are the principal public health defence against influenza, rapid vaccine development can be a daunting task. Antiviral drugs offer the promise of inhibiting influenza regardless of its genetic variations. However, the rapid rise of resistance to several antivirals has highlighted the need for developing novel therapeutics with reduced drug resistance potential. In this review, we will summarize the effects of the currently licensed anti-influenza drugs as well as the candidates in development against the seasonal and the 2009 H1N1 pandemic influenza A virus with an emphasis on drug resistance.

abstract

http://jac.oxfordjournals.org/cgi/content/abstract/65/6/1086

The Global Health Research Forum believes that the highly pathogenic H5N1 strain of the virus could be with us in support of another decade and the opening of this virus mutating into one that can be exchange between humans is still highly likely.It is rightfully accurate that around 750000 family in the could depart this duration in a pandemic.
There is a distressing new report out of Vietnam that appears to indicate that one family there has tried positive for both the H5N1 bird flu and the H1N1 swine flu.
Cagayan Valley is considered a high risk area for bird flu because of location, presence of wetlands and high poultry population.
What avian influenza is and what it can become from a physician that understands not only the bird flu, but what you realistically can and should do to protect the loved ones.
Even if a Bird Flu vaccine is developed, it must still be produced surrounded by mass quantities and that takes months or years.
Many individuals would acknowledge that there is still room for improvement with the lifestyle, and this is a good starting point for protection against the Bird Flu, or indeed any type of infection. Improve the lifestyle.

Further Readings
Rhythmic Breathing Plus Olfactory Nerve Influence on Respiration, Richard B. Noble, 1996
Rice price fluctuation and an approach to price stabilization in Bangladesh, Raisuddin Ahmed, Andrew Bernard, 1989
Influence and removal of organics in drinking water, Jol Mallevialle, I. H. Suffet, U. Sam Chan, 1992
Cherry cheesecake murder, Joanne Fluke, 2006
Schaum’s outline of theory and problems of fluid dynamics, William F. Hughes, John A. Brighton, 1999

External Links
Flu
Protection Against the Swine Flu in Style
Flu

Bird Flu and the anti-Viral Drug Tamiflu is filed under Flu.

More than half the scientists fighting H1N1 ‘pandemic’ have ties to drug companies

UK Daily Mail
January 14, 2010

More than half the scientists on the swine flu taskforce advising the Government have ties to drug companies.

Eleven of the 20 members of the Scientific Advisory Group for Emergencies (SAGE) have done work for the pharmaceutical industry or are linked to it through their universities.

Many have declared interests in GlaxoSmithKline, the vaccine maker expected to be the biggest beneficiary of the pandemic.

The disclosure of the register of interests comes just days after a health expert branded the swine flu outbreak a ‘false pandemic’ driven by the drug companies which stood to profit.

The Government is now trying to offload up to £1billion worth of unwanted swine flu vaccine.

Last July, the Department of Health warned of up 65,000 deaths, with 350 a day at the pandemic’s peak. But the death toll now stands at just 251.

SAGE was created to give Ministers recommendations on how to control and treat the virus.

Official documents show some members are linked to vaccine manufacturer Baxter and to Roche, which makes Tamiflu.

GSK, Baxter and Roche stand to make up to £1.5billion between them from Government contracts related to swine flu.

Read Full Article Here

Dr. Wolfgang Wodarg: WHO and drug companies made ‘false H1N1 claims’

by revere, cross-posted from Effect Measure

Original Post : Myths and Facts about Marijuana
http://www.healthpress.us/myths-and-facts-about-marijuana/

Marijuana is a psychoactive drug extracted from flowering tops of female plants of cannabis sativa. Marijuana has a synthetic form of chemical THC, and used to treat few medical complications. In the United States, FDA has approved marijuana as a treatment option for cancer, and the symptoms of HIV, and influenza. According to Monitoring Future Survey 2007, among the students of 8th, 10th, and 12th grades observed a decline of 20% in marijuana drug abuse compared to last year. Continue Reading

Norway and Britain may have some troubling news regarding the Swine Flu.

A National Emergency of the Swine flu may be improving, at least for now.

Obviously, the Swine flu is far from over. A peak may be seen in America and in Western Europe. The wave of infections seems to be increasing in Eastern Europe and Asia.

Over 6,700 deaths worldwide have been recorded as a direct result of the Swine Flu.

Though, it has been argued, cases may increase in January and several peaks could be seen in the typical single flu season whether human flu or H1N1.

There are “early signs of a peak in disease activity in some areas of the northern hemisphere,” the WHO said in a statement.

Drug-Resistant Swine Flu

The real concern or next phase of concern may be moving to a possible drug resistance by the swine flu virus in certain countries.  The spread of this strain may be occurring in Great Britain.

Importantly, this does not mean a resistance to the vaccine!!

5 individuals in Wales were found to be resistant to the antiviral drug “Tami-flu” from companies Roche AG and Gilead Sciences Inc

These patients did have success with a different antiviral from other companies GlaxoSmithKline and Biota Inc’s “Relenza”.

Each of these patients also had serious immune problems that may have given the strain an opportunity to develop resistance.

Another outbreak is being investigated in Norway where a strain of H1N1 may have mutated causing symptoms that were worse than expected and rather severe.

Recently the Norwegian Institute of Public Health reported that the virus may be able to go deeper into the respiratory system as a result, the symptoms were more serious.

The virus mutation was found on autopsy of two individuals that had died from the Swine flu.

Norway has seen a larger number of deaths per population when compared to other European countries.

Swine Flu Available Vaccines

World production continues to move forward when it comes to the  H1N1 vaccinations.   But truthfully, the world population and the number of vaccines available is quite large.  It is unlikely that a bridge will be able to connect the two sides any time soon.

The United States and several other countries are far behind where they would like to be.  Some countries report a shortage in the vaccine production.   Currently 44 million doses have been shipped so far.    This is only 30% of the anticipated amount.

Plateau

Several countries including the Untied States and Western Europe have experienced a decrease in number of new cases of the Swine flu within the past few weeks.

The question is whether this is a shift or a plateau.  Eastern European countries and Asia have seen an increase in cases.

The next few weeks will be telling for the projection of Swine Flu cases in the New year.